stefantalpalaru

lipid nanoparticles

• "In summary, here we show that the LNPs used for many preclinical studies are highly inflammatory. Thus, their potent adjuvant activity and reported superiority comparing to other adjuvants in supporting the induction of adaptive immune responses could stem from their inflammatory nature. Furthermore, the preclinical LNPs are similar to the ones used for human vaccines, which could also explain the observed side effects in humans using this platform." - "The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory" (2021)

• "Delivery of nucleic acids with positively charged lipid nanoparticles ((+)NPs) is widely used as research reagents and potentially for therapeutics due to their ability to deliver nucleic acids into the cell cytoplasm. However, in most reports little attention has been made to their toxic effects. In the present study, we performed comprehensive

robertodr

{ config, pkgs, options, ... }:
let
  baseConfig = {
    allowUnfree = true;
  };

  unstable = import <nixos-unstable> { config = baseConfig; };
in
{
  imports = [

kfl

(module
  (import "shared" "memory" (memory 1))
  (import "shared" "table" (table 1 anyfunc))
  (elem (i32.const 0) $read1)  ;; set table[0] to read1 for indirect calling

  (func $read1 (result i32)
   i32.const 4
   i32.load)

  (func $read0 (result i32)

wndhydrnt

foo
bar
baz

ErikAugust

#include <stdio.h>
#include <stdlib.h>
#include <stdint.h>
#ifdef _MSC_VER
#include <intrin.h> /* for rdtscp and clflush */
#pragma optimize("gt",on)
#else
#include <x86intrin.h> /* for rdtscp and clflush */
#endif

mjj2000

git describe --exact-match --tags 2> /dev/null || git rev-parse --short HEAD

nathan-osman

package main

import (
	"log"
	"syscall"
	"unsafe"
)

var (
	kernel32 = syscall.NewLazyDLL("kernel32.dll")

davecheney

diff --git a/src/errors/errors.go b/src/errors/errors.go
index b8a4692..ba1e239 100644
--- a/src/errors/errors.go
+++ b/src/errors/errors.go
@@ -10,6 +10,10 @@ func New(text string) error {
        return &errorString{text}
 }
 
+type Error string
+

vasanthk

System Design Cheatsheet

Picking the right architecture = Picking the right battles + Managing trade-offs

Basic Steps

1. Clarify and agree on the scope of the system

• User cases (description of sequences of events that, taken together, lead to a system doing something useful)
  • Who is going to use it?
  • How are they going to use it?

alimbada

#Put this in Export-Chocolatey.ps1 file and run it:
#.\Export-Chocolatey.ps1 > packages.config
#You can install the packages using
#choco install packages.config -y

Write-Output "<?xml version=`"1.0`" encoding=`"utf-8`"?>"
Write-Output "<packages>"
choco list -lo -r -y | % { "   <package id=`"$($_.SubString(0, $_.IndexOf("|")))`" version=`"$($_.SubString($_.IndexOf("|") + 1))`" />" }
Write-Output "</packages>"