sqlalchemy programmatically

connect.py

from alembic.runtime.environment import EnvironmentContext
from alembic.script import ScriptDirectory
from sqlalchemy import create_engine


connectable = create_engine("postgresql+pg8000://some_url".format(connect_args={'ssl_context': True})

alembic_script = ScriptDirectory.from_config(alembic_cfg)
alembic_env = EnvironmentContext(alembic_cfg, alembic_script)

def upgrade_db_to_script_head(revision, context):
    return alembic_script._upgrade_revs(alembic_script.get_heads(), revision)

with connectable.connect() as conn:
    alembic_env.configure(connection=conn, target_metadata=None, fn=upgrade_db_to_script_head)

    with alembic_env.begin_transaction():
        alembic_env.run_migrations()